Valproic Acid Downregulates the Expression of MGMT and Sensitizes Temozolomide-Resistant Glioma Cells

Figure 6

Inhibition of the growth of T98 xenografts treated with VPA and TMZ. BALB/c nude mice bearing T98 cells were distributed into four treatment groups: filled circle, PSB; open circle, VPA (300 mg/kg); filled triangle, TMZ (50 mg/kg); open triangle, VPA (300 mg/kg) + TMZ (50 mg/kg). Points, mean; bars, SE. ^∗∗𝑃<0.01, ANOVA. PBS was used as a control. The results are representative of two independent experiments.