1,25-Dihydroxyvitamin D3 Inhibits the RANKL Pathway and Impacts on the Production of Pathway-Associated Cytokines in Early Rheumatoid Arthritis

<table>The levels of RANKL/OPG after treatment with 1,25(OH)<sub>2</sub>D<sub>3</sub>,   MTX, and 1,25(OH)<sub>2</sub>D<sub>3</sub> plus MTX in RA patients. The RA patients’ PBMCs are treated with either anti-CD3/CD28, or 1,25(OH)<sub>2</sub>D<sub>3</sub> and MTX at various concentrations, or the combination of 1,25(OH)<sub>2</sub>D<sub>3</sub> and MTX (D2M2 group). There was no difference in RANKL/OPG expression between the groups of 1,25(OH)<sub>2</sub>D<sub>3</sub>,   MTX, and D2M2 and the group of vehicle (<svg height="11.375" id="M29" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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BioMed Research International

fig6

Figure 6

Figure 6: 1,25-Dihydroxyvitamin D3 Inhibits the RANKL Pathway and Impacts on the Production of Pathway-Associated Cytokines in Early Rheumatoid Arthritis 

Figure 6 | 1,25-Dihydroxyvitamin D3 Inhibits the RANKL Pathway and Impacts on the Production of Pathway-Associated Cytokines in Early Rheumatoid Arthritis 