Table 1: Amino acid composition of native PhTX-I and their chemically modified derivatives.

Amino acidPhTX-I nativeaPhTX-I modifiedbPhTX-I modifiedcPhTX-I modifieddPhTX-I modifiede

Asp1110.92 (11)10.9 (11)10.72 (11)10.56 (11)
Glu65.98 (6)6.12 (6)5.92 (6)6.37 (6)
Ser33.37 (3)3.15 (3)3.21 (3)3.03 (3)
Gly1111.43 (11)11.25 (11)11.39 (11)11.13 (11)
His21.74 (2)1.94 (2)1.6 (2)0.65 (1)
Arg77.62 (7)6.56 (7)7.15 (7)7.42 (7)
Thr66.34 (6)6.09 (6)6.35 (6)6. 34 (6)
Ala54.81 (5)5.29 (5)5.34 (5)5.44 (5)
Pro65.82 (6)6.01 (6)6.05 (6)5.74 (6)
Tyr1010.24 (10)9.79 (10)5.94 (6)10.21 (10)
Val33.33 (3)3.34 (3)3.49 (3)3.49 (3)
Met11.47 (1)1.17 (1)1.18 (1)1.45 (1)
Cys1413.96 (14)13.98 (14)13.74 (14)13.69 (14)
Ile22.47 (2)2.35 (2)2.27 (2)2.22 (2)
Leu88.29 (8)8.44 (8)8.12 (8)8.01 (8)
Phe43.58 (4)4.49 (4)4.74 (4)4.21 (4)
Lys1710.02 (10)16.93 (17)17.35 (17)17.2 (17)
Trp3NDNDNDND

aAmino acid sequence. Amino acid analysis of chemical modifications with bAA (Lys), cNPSC (Trp), dNBSF (Tyr), and eBPB (His). ND: nondetermined.