Extending the Serum Half-Life of G-CSF via Fusion with the Domain III of Human Serum Albumin

Table 1

Pharmacokinetic parameters of G-CSF and 3DHSA-G-CSF from noncompartmental analysis.

Parameter	Unit	G-CSF	3DHSA-G-CSF
𝑡1/2	h	2.071±0.037	3.425±0.098^∗∗
𝑇max	h	1.459±0.021	2.097±0.128^∗∗
𝐶max	ng/mL	2224±1.425	2314±280.1
AUC	h·ng/mL	8511±244.7	16339±1316^∗∗
MRT	h	3.091±0.113	5.550±0.339^∗∗
Vz/F	mL/kg	351.1±5.507	303.3±17.00^∗∗
Cl/F	mL/h/kg	117.5±3.414	61.48±5.191^∗∗

Values are expressed as mean ± SD (𝑛=3).
SC: subcutaneous; 𝑡_1/2: terminal half-life; 𝑇_max: time of maximum concentration; 𝐶_max: maximum concentration; AUC: area under the curve; MRT: mean residence time; Vz/F: volume of distribution over bioavailability; CL/F: clearance over bioavailability.
The half-life of 3DHSA-G-CSF is longer than G-CSF and showed significant.
^∗∗𝑃<0.01 versus G-CSF.