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BioMed Research International
Volume 2013 (2013), Article ID 109219, 7 pages
http://dx.doi.org/10.1155/2013/109219
Clinical Study

Prevalence of Bronchiectasis in Asthma according to Oral Steroid Requirement: Influence of Immunoglobulin Levels

1Servei de Pneumologia, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí, Parc Taulí 1, Sabadell, 08208 Barcelona, Spain
2Departament de Medicina, Universitat Autònoma de Barcelona (UAB), Campus de la UAB, Cerdanyola del Vallès, 08193 Barcelona, Spain
3Ciber de Enfermedades Respiratorias (CIBERES), Carretera Soller Km 12, Illes Balears, 07110 Bunyola, Spain
4Servei de Diagnòstic per la Imatge, UDIAT, Corporació Sanitària i Universitària Parc Taulí, Parc Taulí 1, Sabadell, 08208 Barcelona, Spain
5Servei de Laboratori, UDIAT, Corporació Sanitària i Universitària Parc Taulí, Parc Taulí 1, Sabadell, 08208 Barcelona, Spain
6Servei de Pediatria, Unitat de Pneumologia, Al.lèrgia i Fibrosi Quística, UDIAT, Corporació Sanitària i Universitària Parc Taulí, Parc Taulí 1, Sabadell, 08208 Barcelona, Spain
7Departament de Ciències Morfològiques, Universitat Autònoma de Barcelona (UAB), Campus de la UAB, Cerdanyola del Vallès, 08193 Barcelona, Spain

Received 3 June 2013; Revised 1 October 2013; Accepted 1 October 2013

Academic Editor: Edineia Lemos Andrade

Copyright © 2013 Manel Luján et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To establish the prevalence of bronchiectasis in asthma in relation to patients’ oral corticosteroid requirements and to explore whether the increased risk is due to blood immunoglobulin (Ig) concentration. Methods. Case-control cross-sectional study, including 100 sex- and age-matched patients, 50 with non-steroid-dependent asthma (NSDA) and 50 with steroid-dependent asthma (SDA). Study protocol: (a) measurement of Ig and gG subclass concentration; (b) forced spirometry; and (c) high-resolution thoracic computed tomography. When bronchiectasis was detected, a specific etiological protocol was applied to establish its etiology. Results. The overall prevalence of bronchiectasis was 12/50 in the SDA group and 6/50 in the NSDA group ( ). The etiology was documented in six patients (four NSDA and two SDA). After excluding these patients, the prevalence of bronchiectasis was 20% (10/50) in the SDA group and 2/50 (4%) in the NSDA group ( ). Patients with asthma-associated bronchiectasis presented lower FEV1 values than patients without bronchiectasis, but the levels of Ig and subclasses of IgG did not present differences. Conclusions. Steroid-dependent asthma seems to be associated with a greater risk of developing bronchiectasis than non-steroid-dependent asthma. This is probably due to the disease itself rather than to other influencing factors such as immunoglobulin levels.