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BioMed Research International
Volume 2013 (2013), Article ID 121684, 10 pages
http://dx.doi.org/10.1155/2013/121684
Review Article

Illuminating the Petite Picture of T Cell Memory Responses to Listeria monocytogenes

1Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India
2Women’s College, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002, India

Received 17 June 2013; Accepted 25 July 2013

Academic Editor: Anshu Agrawal

Copyright © 2013 Saba Tufail et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The ease to culture, moderately less safety constraints in handling, and above all, hurdle free induction of an anticipated infection in mouse rendered Listeria monocytogenes the rank of a model organism for studying a variety of host immune responses. Listeria monocytogenes being an intracellular pathogen evokes potent CD8 T cell response during which CD8 T cells pass through a massive expansion phase. This is generally followed by contraction phase wherein majority of activated cells undergo apoptosis leaving behind a population of memory CD8 T cells that has potential to confer enhanced protection upon reencounter with the same pathogen. Functional attributes of various cytokines, transcription factors, receptors, adaptors, and effectors pertaining to the generation of robust memory T cell response have begun to be unravelled for better understanding of memory and opening avenues to create superior vaccine strategies. This review is an attempt to unveil related discoveries along with updating recent advances on this issue.