A Novel Bone Morphogenetic Protein 2 Mutant Mouse, nBmp2NLS^tm, Displays Impaired Intracellular Ca²⁺ Handling in Skeletal Muscle

Figure 4

nBMP2 is detectable in myonuclei of wild type but notnBmp2NLS^tmmice. Gastrocnemius muscles were sectioned and stained by immunohistochemistry. (a)–(d) are wild type; (e)–(h) are mutant. (a) and (e) show sections at 40x magnification, and all other panels show 100x. The brown BMP2 antibody stain is evident in myonuclei of wild type muscle, whereas myonuclei stain pale blue in the mutant muscle. Arrows indicate some (but not all) of the myonuclei.

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