126189.fig.004a
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126189.fig.004b
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Figure 4: Generation of functional OVA-specific CD8+ effector T cells following immunization with IL-6-deficient DCs.Mice were immunized as in Figure 3 and effector molecules production was analyzed following a short in vitro stimulation with the OVA peptide. The overlays show production of the different effector molecules by OVA-specific Te cells (CD8+CD45.2+) compared to endogenous T cells (CD8+CD45.2) at day 4 post-immunization with WT (left) or IL-6 KO (right) DCs. The MFI of effector molecule expression by OVA-specific CD8+ effectors (upper bold number) and endogenous CD8+ T cells (lower number) are indicated on each overlay.