HOXA4 Gene Promoter Hypermethylation as an Epigenetic Mechanism Mediating Resistance to Imatinib Mesylate in Chronic Myeloid Leukemia Patients

Table 1

Methylation percentage frequencies of HOXA4 gene in IM resistant and good response CML patients.

HOXA4 methylation (%)	Normal Control	CML Patients	𝑃 value	CML Patients
				Good Response	Resistance	𝑃 value
0–24	6	6	0.000*	4	2	0.213
25–49	6	16	0.016*	11	5	0.010*
50–74	0	43	0.001*	18	25	0.736
75–100	0	30	0.018*	5	25	0.002*

*Chi-Square test, 𝑃<0.05 significant at 95% CI.