A BCR/ABL-hIL-2 DNA Vaccine Enhances the Immune Responses in BALB/c Mice
Figure 5
Histological examination of quadriceps muscle at injection sites. Inflammatory cell infiltration was detected by HE stain (10x). Mice were administered with saline (a), empty plasmid (b), BCR/ABL-pIRES (c), BCR/ABL-pIRES-hIL-2 (d), and pIRES-hIL-2 (e). Moderate inflammatory cell infiltration (d), mild inflammation ((c) and (e)). The expressions of BCR/ABL were detected by immunohistochemistry (DAB staining, 10x). Muscle from immunized mice with the BCR/ABL-pIRES-hIL-2 (g) and BCR/ABL-pIRES (h) showed a predominant staining pattern while the empty plasmid did not (f).
