In Vitro Release Kinetics of Antituberculosis Drugs from Nanoparticles Assessed Using a Modified Dissolution Apparatus

Table 3

Kinetic assessment of release data of RIF-Gel-NPs in diverse buffers (𝑄<0.6).

Method	Drug loading (w/w)	Media	Korsmeyer-Peppas
			𝑛^a	𝑅^2b
Modified cylinder method	21.6%	pH 7.4	0.4254	0.9541
		pH 4.0	0.3543	0.9478
		pH 7.4-trypsin	0.5501	0.8854
		pH 4.0-trypsin	0.5728	0.9636
	56.7%	pH 7.4	0.3911	0.9245
		pH 7.4-trypsin	0.5432	0.9774
Dialysis bag technique	21.6%	pH 7.4	0.6764	0.9721
		pH 4.0	0.5472	0.9760
	56.7%	pH 7.4	0.2779	0.9397
		pH 4.0	0.2555	0.9842
		pH 7.4-trypsin	0.2994	0.9098
		pH 4.0-trypsin	0.2744	0.9772

aDiffusional exponent and ^bsquared correlation coefficient.