Research Article
Association Study of Single Nucleotide Polymorphisms in XRCC1 Gene with Risk of Hepatocellular Carcinoma in Chinese Han Population
Table 4
Association between hepatocellular carcinoma (HCC) risk and XRCC1 gene polymorphisms.
| | SNPs | Comparisons | Test of association | | OR (95% CI) | value | value |
| | c.1254C>T | Homozygote comparison (TT vs. CC) | 2.30 (1.61–3.28) | 21.59 | <0.001 | | Heterozygote comparison (CT vs. CC) | 1.32 (1.05–1.67) | 5.58 | 0.018 | | Dominant model (TT/CT vs. CC) | 1.50 (1.20–1.86) | 12.96 | <0.001 | | Recessive model (TT vs. CT/CC) | 2.00 (1.43–2.80) | 16.73 | <0.001 | | Allele contrast (T vs. C) | 1.47 (1.25–1.73) | 21.97 | <0.001 |
| | c.1517G>C | Homozygote comparison (CC vs. GG) | 1.90 (1.34–2.69) | 13.22 | <0.001 | | Heterozygote comparison (GC vs. GG) | 1.56 (1.24–1.97) | 14.04 | <0.001 | | Dominant model (CC/GC vs. GG) | 1.63 (1.31–2.03) | 19.15 | <0.001 | | Recessive model (CC vs. GC/GG) | 1.52 (1.10–2.11) | 6.33 | 0.012 | | Allele contrast (C vs. G) | 1.45 (1.23–1.70) | 20.10 | <0.001 |
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SNPs: single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval; vs.: versus.
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