Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits

Table 1

Mean (±SD) pharmacokinetic parameters of zonisamide in pregnant and nonpregnant rabbits.

Parameter	Nonpregnant	Pregnant	𝑃 value^a
𝑇max (h)	4.33±1.97	3.33±1.03	0.344
𝐶max (𝜇g/mL)	10.24±2.90	7.21±1.84	0.036
𝑡1/2abs (h)	1.86±1.62	0.94±0.36	0.313
𝑡1/2el (h)	13.72±5.11	10.84±3.43	0.313
MRT (h)	20.92±6.44	16.38±5.17	0.156
AUC0--𝑡 (𝜇g·h/mL)	150.35±36.70	97.88±24.87	0.031
AUC0--∞ (𝜇g·h/mL)	213.86±45.59	124.10±31.60	0.031
Vd/F (L/kg)	0.98±0.51	1.32±0.59	0.313
CL/F (mL/min/kg)	0.82±0.21	1.40±0.27	0.031

𝑇_max: time needed to reach maximum plasma concentration; 𝐶_max: maximum plasma concentration; 𝑡_1/2abs: absorption half-life; 𝑡_1/2el: elimination half-life; MRT: mean residence time; AUC_0--𝑡: area under the plasma concentration-time curve from time 0 to time of last quantifiable concentration; AUC_0--∞: area under the plasma concentration-time curve from time 0 to infinity; Vd/F: volume of distribution; CL/F: oral clearance.
^aStatistically significant if 𝑃<0.05, using Wilcoxon matched-pair signed-rank test; 𝑛=7.