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BioMed Research International
Volume 2013 (2013), Article ID 141427, 7 pages
Review Article

Characterization and In Vivo Biological Performance of Biosilicate

1Department of Biosciences, Federal University of São Paulo, Avenida Ana Costa 95, 11060-001 Santos, SP, Brazil
2Vitreous Materials Laboratory, Department of Materials Engineering, Federal University of São Carlos, Rodovia Washington Luís (SP-310), Km 235, 13565-905 São Carlos, SP, Brazil
3Department of Physiotherapy, Federal University of São Carlos, Rodovia Washington Luís (SP-310), Km 235, 13565-905 São Carlos, SP, Brazil

Received 6 May 2013; Accepted 18 July 2013

Academic Editor: Stanley J. Stachelek

Copyright © 2013 Ana Claudia M. Renno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


After an introduction showing the growing interest in glasses and glass-ceramics as biomaterials used for bone healing, we describe a new biomaterial named Biosilicate. Biosilicate is the designation of a group of fully crystallized glass-ceramics of the Na2O-CaO-SiO2-P2O5 system. Several in vitro tests have shown that Biosilicate is a very active biomaterial and that the HCA layer is formed in less than 24 hours of exposure to “simulated body fluid” (SBF) solution. Also, in vitro studies with osteoblastic cells have shown that Biosilicate disks supported significantly larger areas of calcified matrix compared to 45S5 Bioglass, indicating that this bioactive glass-ceramic may promote enhancement of in vitro bone-like tissue formation in osteogenic cell cultures. Finally, due to its special characteristics, Biosilicate has also been successfully tested in several in vivo studies. These studies revealed that the material is biocompatible, presents excellent bioactive properties, and is effective to stimulate the deposition of newly formed bone in animal models. All these data highlight the huge potential of Biosilicate to be used in bone regeneration applications.