| Cell||Function||Role in IBD||IL-33 effect|
|Goblet cell||Secretion of mucin, TFF3 and RELM-β.||Aberrant accumulation of mucin. Low TFF3 secretion.||Mucosecretagogue activity.|
Intestinal antigenic tolerance.
|Loss of tolerance.|
Increased CD14 and NF-κB expression.
|Secretion of TNF, IL-1β, CXCL1, and CCL3.|
|Basophil mast cell||Defense against parasites. |
|Controversial.||Increased expression of surface ST2. |
Th2 cytokine secretion.
Synergistically increases the IgE-mediated degranulation.
|Eosinophil||Defense against parasites. |
|Higher eosinophilic protein content in feces and intestinal fluid. ||Production of superoxide, IL-3, IL-5, IL-8, and GM-CSF.|
|Dendritic cell||Antigen presentation.|
|Accumulation in inflamed area.|
Increased expression of TLR2, TLR4, and CD40.
|Increases expression of MCH-II, CD86, and IL-6. |