About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 143202, 7 pages
http://dx.doi.org/10.1155/2013/143202
Clinical Study

Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma

1Fondazione IRCSS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
2Department of Pathology, S. Chiara Hospital, Largo Medaglie Oro 9, 38122 Trento, Italy

Received 21 January 2013; Accepted 24 July 2013

Academic Editor: Manoor Prakash Hande

Copyright © 2013 Marina Bagnoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Guarneri, F. Piacentini, E. Barbieri, and P. F. Conte, “Achievements and unmet needs in the management of advanced ovarian cancer,” Gynecologic Oncology, vol. 117, no. 2, pp. 152–158, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Vaughan, J. I. Coward, R. C. Bast Jr. et al., “Rethinking ovarian cancer: recommendations for improving outcomes,” Nature Reviews Cancer, vol. 11, no. 10, pp. 719–725, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. R. C. Bast Jr., B. Hennessy, and G. B. Mills, “The biology of ovarian cancer: new opportunities for translation,” Nature Reviews Cancer, vol. 9, no. 6, pp. 415–428, 2009. View at Scopus
  4. F. Muggia, “Platinum compounds 30 years after the introduction of cisplatin: implications for the treatment of ovarian cancer,” Gynecologic Oncology, vol. 112, no. 1, pp. 275–281, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J.-P. Gillet, T. Efferth, and J. Remacle, “Chemotherapy-induced resistance by ATP-binding cassette transporter genes,” Biochimica et Biophysica Acta, vol. 1775, no. 2, pp. 237–262, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. M. M. Gottesman, T. Fojo, and S. E. Bates, “Multidrug resistance in cancer: role of ATP-dependent transporters,” Nature Reviews Cancer, vol. 2, no. 1, pp. 48–58, 2002. View at Scopus
  7. P. Borst, R. Evers, M. Kool, and J. Wijnholds, “A family of drug transporters: the multidrug resistance-associated proteins,” Journal of the National Cancer Institute, vol. 92, no. 16, pp. 1295–1302, 2000. View at Scopus
  8. J. I. Fletcher, M. Haber, M. J. Henderson, and M. D. Norris, “ABC transporters in cancer: more than just drug efflux pumps,” Nature Reviews Cancer, vol. 10, no. 2, pp. 147–156, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. G. L. Beretta, V. Benedetti, G. Cossa et al., “Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin,” Biochemical Pharmacology, vol. 79, no. 8, pp. 1108–1117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. G. D. Leonard, T. Fojo, and S. E. Bates, “The role of ABC transporters in clinical practice,” Oncologist, vol. 8, no. 5, pp. 411–424, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Sassi, Y. Hara, A.-M. Lompré, and J.-S. Hulot, “Multi-drug resistance protein 4 (MRP4/ABCC4) and cyclic nucleotides signaling pathways,” Cell Cycle, vol. 8, no. 7, pp. 962–963, 2009. View at Scopus
  12. D. Aldovini, F. Demichelis, C. Doglioni et al., “M-CAM expression as marker of poor prognosis in epithelial ovarian cancer,” International Journal of Cancer, vol. 119, no. 8, pp. 1920–1926, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. L. Berman, “Future directions in the surgical management of ovarian cancer,” Gynecologic Oncology, vol. 90, no. 2, pp. S33–S39, 2003. View at Scopus
  14. A. B. Miller, B. Hoogstraten, M. Staquet, and A. Winkler, “Reporting results of cancer treatment,” Cancer, vol. 47, no. 1, pp. 207–214, 1981. View at Scopus
  15. G. Bertolini, L. Roz, P. Perego et al., “Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 38, pp. 16281–16286, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Aguilar-Mahecha, S. Hassan, C. Ferrario, and M. Basik, “Microarrays as validation strategies in clinical samples: tissue and protein microarrays,” OMICS, vol. 10, no. 3, pp. 311–326, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. M. D. Norris, J. Smith, K. Tanabe et al., “Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro,” Molecular Cancer Therapeutics, vol. 4, no. 4, pp. 547–553, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Haber, J. Smith, S. B. Bordow et al., “Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma,” Journal of Clinical Oncology, vol. 24, no. 10, pp. 1546–1553, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Harter, F. Hilpert, S. Mahner, F. Heitz, J. Pfisterer, and A. D. Bois, “Systemic therapy in recurrent ovarian cancer: current treatment options and new drugs,” Expert Review of Anticancer Therapy, vol. 10, no. 1, pp. 81–88, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Faggad, S. Darb-Esfahani, R. Wirtz et al., “Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis,” Histopathology, vol. 54, no. 6, pp. 657–666, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Vander Borght, M. Komuta, L. Libbrecht et al., “Expression of multidrug resistance-associated protein 1 in hepatocellular carcinoma is associated with a more aggressive tumour phenotype and may reflect a progenitor cell origin,” Liver International, vol. 28, no. 10, pp. 1370–1380, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Gatti, G. L. Beretta, G. Cossa, F. Zunino, and P. Perego, “ABC transporters as potential targets for modulation of drug resistance,” Mini-Reviews in Medicinal Chemistry, vol. 9, no. 9, pp. 1102–1112, 2009. View at Publisher · View at Google Scholar · View at Scopus