Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma

Table 4

Univariate analysis of the prognostic impact of clinical covariates and MRPs on progression-free survival in high-grade EOC.

	𝑃^∗	HR	(95% CI)
Stage
III-IV versus I-II	<0.0001	7.78	3.85–15.7
Histotype
Serous versus; others	0.011	1.9	1.16–3.12
Surgical debulking
SOD versus OD	<0.0001	3.4	2.09–5.52
Age at diagnosis
>55 versus ≤55	0.48	1.17	0.76–1.8
MRP1 expression
Positive versus; negative	0.86	0.96	0.6–1.53
MRP4 expression
Positive versus; negative	0.27	1.35	0.8–2.28

^∗𝑃 value determined using log-rank test; HR: hazard ratio; CI: confidence interval; SOD: suboptimal debulking (residual disease >1 cm), OD: optimal debulking (residual disease not evident or <1 cm).