Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study
Table 3
MSA and PSP patients with SPECT: diagnoses, gender, subtype, and SPECT per timepoint.
Gender
Diagnosis
Motor Subtype
SPECT timepoint
Baseline
First year
Third year
DAT
IBZM
DAT
IBZM
DAT
IBZM
MSA
Male
MSA prob. (+PD prob.)
PIGD
*
*
*
*
X
X
Female
MSA prob.
PIGD
*
*
*
*
X
X
Male
MSA prob.
PIGD
*
*
X
X
X
X
Male
MSA prob. (+PD prob.)
PIGD
*
*
X
X
X
X
Male
MSA prob.
PIGD
*
*
X
X
X
Female
MSA poss. (+PD def.)
Indeterm.
X
X
X
X
Female
MSA prob.
PIGD
X
X
Male
MSA prob.
PIGD
X
X
X
X
Female
MSA prob.
PIGD
X
X
Male
MSA poss. (+PD prob.)
Tremor
X
X
X
X
Male
MSA poss. (+PD def.)
PIGD
X
X
X
X
X
X
Male
MSA prob. (+PD def.)
Tremor
X
X
X
X
Total (male/female)
12 (8/4)
7 (4/3)
6 (4/2)
8 (7/1)
8 (7/1)
7 (5/2)
5 (4/1)
PSP
Female
PSP poss.
Indeterm.
*
*
X
X
Male
PSP poss.
PIGD
*
*
X
X
Female
PSP prob.
PIGD
*
*
X
X
X
Female
PSP PAGF
PIGD
X
X
X
X
X
Male
PSP poss.
PIGD
X
X
X
X
X
X
Male
PSP prob.
PIGD
X
X
X
X
X
X
Male
PSP poss.
Indeterm.
X
X
X
X
X
Female
PSP poss. (+PD def.)
PIGD
X
X
X
Male
PSP poss. (+PD prob.)
PIGD
X
X
X
X
Female
PSP prob.
PIGD
X
X
Male
PSP prob.
PIGD
X
X
Female
PSP prob.
PIGD
X
X
X
X
Female
PSP prob.
PIGD
X
X
X
X
Male
PSP poss.
Tremor
X
X
X
X
Male
PSP prob.
PIGD
X
X
Female
PSP prob.
PIGD
X
Total (male/female)
16 (8/8)
13 (7/6)
12 (7/5)
12 (6/6)
10 (6/4)
3 (2/1)
5 (3/2)
The patients fulfilled the established criteria for diagnosis of MSA according to Gilman et al., 1999 [18] or of PSP according to Litvan et al., 1996 [19]. Some patients also fulfilled criteria for PD according toGibb and Lees1988 [20] (diagnosis put in brackets). Field with *: SPECT was made on another camera; prob.: probable; PAGF: pure akinesia with gait freezing; poss.: possible; def.: definitive; PIGD: postural instability and gait difficulty; Indeterm.: Indeterminate.
