Table 6: DAT and IBZM SPECT uptake in HC, PD, MSA, and PSP by region and SPECT timepoint.
(a)

Baseline
HC
DAT
IBZM
PD
DAT
IBZM
MSA
DAT
IBZM
PSP
DAT
IBZM
Mann-Whitney U test
Mean95% CIMean95% CIPD
versus HC
Mean95% CIMSA
versus HC
Mean95% CIPSP
versus HC
PD
versus MSA
PD
versus PSP
MSA
versus PSP
P * P * P * P P P

Caudate DAT4.474.14–4.803.182.94–3.42<0.0013.192.43–3.95<0.0012.832.50–3.15<0.001nsns(0.075)
Putamen DAT4.093.83–4.362.472.32–2.63<0.0012.742.16–3.31<0.0012.312.01–2.61<0.001nsns(0.075)
Striate DAT4.273.98–4.562.802.61–2.98<0.0012.952.31–3.59<0.0012.552.25–2.85<0.001nsns(0.063)

Striate IBZM1.821.74–1.911.791.73–1.851.001.841.66–2.031.001.791.70–1.881.00nsnsns

(b)

Year 1
PD
DAT
IBZM
MSA
DAT
IBZM
PSP
DAT
IBZM
Mann-Whitney U test
Mean95% CIMean95% CIMean95% CIPD
versus MSA
PD
versus PSP
MSA
versus PSP
P P

Caudate DAT2.962.70–3.223.583.13–4.022.782.43–3.130.024ns0.007
Putamen DAT2.282.13–2.432.562.25–2.872.171.89–2.46(0.060)ns0.025
Striate DAT2.592.40–2.793.022.67–3.382.452.15–2.760.029ns0.014

Striate IBZM1.731.67–1.781.881.71–2.051.641.49–1.78(0.051)ns0.026

(c)

Year 3
HC
DAT
IBZM
PD
DAT
IBZM
MSA
DAT
IBZM
PSP
DAT
IBZM
Mann-Whitney U test
Mean95% CIMean95% CIPD
versus HC
Mean95% CIMSA
versus HC
Mean95% CIPSP
versus HC
PD
versus MSA
PD
versus PSP
MSA
versus PSP
P * P * P * P P P

Caudate DAT4.354.06–4.632.832.55–3.12<0.0012.702.28–3.12<0.0012.381.80–2.96<0.001nsnsns
Putamen DAT3.963.71–4.212.131.97–2.30<0.0012.031.80–2.26<0.0011.921.50–2.34<0.001nsnsns
Striate DAT4.143.88–4.402.452.24–2.67<0.0012.332.03–2.63<0.0012.121.64–2.61<0.001nsnsns

Striate IBZM1.701.65–1.751.661.61–1.721.01.921.71–2.130.0031.701.57–1.831.000.002ns0.016

Left and right uptake ratios are averaged.*One way ANOVA, Bonferroni post-hoc test P value. 95% CI: 95% confidence interval.