Pre- and Postsynaptic Dopamine SPECT in Idiopathic Parkinsonian Diseases: A Follow-Up Study

Table 7

Yearly change (%) in uptake between baseline and 1-year followup: DAT and IBZM ratios.

	N	Mean	95% CI	Mann-Whitney U test
				HC versus PD	HC versus MSA	HC versus PSP	PD versus MSA	PD versus PSP	MSA versus; PSP
				P	P	P	P	P	P
Contralateral^∞
Caudate DAT
PD	27	−8.0	−11.6–−4.5	0.005	ns	0.006	0.013	ns	0.017
MSA	4	5.3	−4.8–15.4
PSP	8	−11.8	−21.0–−2.7
HC*	14	−0.5	−2.2–1.3
Putamen DAT
PD	27	−6.5	−10.8–−2.2	ns	ns	0.006	ns	ns	ns
MSA	4	−3.3	−14.4–7.8
PSP	8	−13.9	−23.0–−4.7
HC*	13	−1.0	−2.9–0.8
Striate DAT
PD	27	−7.2	−10.6–−3.9	0.006	ns	0.004	ns	ns	0.042
MSA	4	0.8	−10.4–11.9
PSP	8	−12.8	−21.6–−4.0
HC*	14	−0.7	−2.4–0.9
Ipsilateral^∞
Caudate DAT
PD	27	−7.7	−12.1–−3.4	0.045	ns	0.006	0.045	ns	ns
MSA	4	4.3	−12.3–21.0
PSP	8	−11.9	−24.8–1.1
HC*	14	−0.5	−2.2–1.3
Putamen DAT
PD	27	−8.5	−12.0–−4.9	0.006	ns	0.005	ns	(0.054)	ns
MSA	4	−8.2	−28.0–11.5
PSP	8	−13.4	−26.9–0.1
HC*	13	−1.0	−2.9–0.8
Striate DAT
PD	27	−8.3	−11.7–−5.0	0.002	ns	0.004	ns	ns	ns
MSA	4	−1.9	−19.2–15.4
PSP	8	−12.8	−25.5–0.0
HC*	14	−0.7	−2.4–0.9
Mean
Striate IBZM
PD	29	−3.1	−6.2–0.0	ns	ns	ns	ns	ns	ns
MSA	5	−4.7	−8.7–−0.7
PSP	8	−8.3	−19.8–3.3
HC*	14	−2.1	−3.5–−0.8

∗HC: average yearly change calculated between baseline and the 3-year follow-up SPECT.
^∞Patients with same laterality as baseline.