Research Article

Phylogeny, Functional Annotation, and Protein Interaction Network Analyses of the Xenopus tropicalis Basic Helix-Loop-Helix Transcription Factors

Table 3

Significant pathways identified by KOBAS with 93 Xenopus tropicalis bHLH transcription factors.

TermPathway databaseDatabase IDSample gene numberBackground numberP valueCorrected P valueGenes

Circadian rhythm: mammalKEGGxtr04710321 0.0001219XSBmal2; XSDec2; XSClock
TGF-beta signaling pathwayKEGGxtr04350473 0.0001219XSId3; XSId2; XSId4; XSnMyc
Notch signaling pathwayPANTHERP00045250.00045160.0024084XSHes1a; XSHes1b; XSHerp1
Notch signaling pathwayKEGGxtr043302430.00376670.0150668XSHes1a; XSHes1b; XSHes5a
Developmental biologyReactomeNone21060.01454010.0398896XSHes1a; XSHes1b; XSNDF1; XSNDF2
Circadian clockReactomeNone180.01495860.0398896XSClock
Herpes simplex infectionKEGGxtr0516821280.03041560.0695215XSBmal2; XSClock
MAPK signaling pathwayKEGGxtr0401022200.08022420.1604484XSMAX; XSnMyc
Fanconi anemia pathwayKEGGxtr034601510.10443070.1856547XSHes1a; XSHes1b
ErbB signaling pathwayKEGGxtr040121700.14062560.2250009XSnMyc
MelanogenesisKEGGxtr049161860.17002610.2386888XSMITF
Jak-STAT signaling pathwayKEGGxtr046301910.17901660.2386888XSnMyc
MetabolismReactomeNone24580.2068350.2544026XSSRC2; XSSRC1
Cell cycleKEGGxtr0411011160.22260230.2544026XSnMyc
Wnt signaling pathwayKEGGxtr0431011310.24769160.2642044XSnMyc
Wnt signaling pathwayPANTHERP000571370.27567720.2756772XSvMyc