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BioMed Research International
Volume 2013 (2013), Article ID 146079, 11 pages
The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population
1Campinas State University, Rua Carlos Chagas 480, Barão Geraldo, 13083878 Campinas, SP, Brazil
2Basic Health Sciences Department, Maringa State University, Avenue Colombo 5790, 87020900 Maringá, PR, Brazil
3Pathology Sciences Department, Londrina State University, Rodovia Celso Garcia Cid (PR 445), 86051-970 Londrina, PR, Brazil
4Department of Clinical Analysis and Biomedicine, Maringa State University, Avenue Colombo 5790, 87020900 Maringá, PR, Brazil
5Program of Biosciences Applied to Pharmacy, Department of Clinical Analysis and Biomedicine, Maringa State University, Avenue Colombo 5790, 87020900 Maringá, PR, Brazil
Received 29 March 2013; Revised 5 June 2013; Accepted 15 June 2013
Academic Editor: Enrique Medina-Acosta
Copyright © 2013 Amanda Vansan Marangon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Schiffman, P. E. Castle, J. Jeronimo, A. C. Rodriguez, and S. Wacholder, “Human papillomavirus and cervical cancer,” The Lancet, vol. 370, no. 9590, pp. 890–907, 2007.
- D. Subramanya and P. D. Grivas, “HPV and cervical cancer: updates on an established relationship,” Postgraduate Medicine, vol. 120, no. 4, pp. 7–13, 2008.
- C. D. Woodworth, “HPV innate immunity,” Frontiers in Bioscience, vol. 7, pp. d2058–d2071, 2002.
- M. H. Hibma, “The immune response to papillomavirus during infection persistence and regression,” The Open Virology Journal, vol. 6, pp. 241–248, 2012.
- T. Sasagawa, H. Takagi, and S. Makinoda, “Immune responses against human papillomavirus (HPV) infection and evasion of host defense in cervical cancer,” Journal of Infection and Chemotherapy, vol. 18, no. 6, pp. 807–815, 2012.
- A. Sharma, M. Rajappa, A. Satyam, and M. Sharma, “Cytokines ( and ) in patients with advanced cervical cancer undergoing neoadjuvant chemoradiation correlation with treatment response,” International Journal of Gynecological Cancer, vol. 19, no. 7, pp. 1269–1275, 2009.
- S. Rajagopalan and E. O. Long, “Understanding how combinations of HLA and KIR genes influence disease,” Journal of Experimental Medicine, vol. 201, no. 7, pp. 1025–1029, 2005.
- R. N. Germain and D. H. Margulies, “The biochemistry and cell biology and antigen processing and presentation,” Annual Review of Immunology, vol. 11, pp. 403–450, 1993.
- D. M. Turner, D. M. Williams, D. Sankaran, M. Lazarus, P. J. Sinnott, and I. V. Hutchinson, “An investigation of polymorphism in the interleukin-10 gene promoter,” European Journal of Immunogenetics, vol. 24, no. 1, pp. 1–8, 1997.
- K. M. Kroeger, K. S. Carville, and L. J. Abraham, “The -308 tumor necrosis factor-α promoter polymorphism effects transcription,” Molecular Immunology, vol. 34, no. 5, pp. 391–399, 1997.
- D. Fishman, G. Faulds, R. Jeffey et al., “The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis,” Journal of Clinical Investigation, vol. 102, no. 7, pp. 1369–1376, 1998.
- V. Pravica, A. Asderakis, C. Perrey, A. Hajeer, P. J. Sinnott, and I. V. Hutchinson, “In vitro production of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene,” European Journal of Immunogenetics, vol. 26, no. 1, pp. 1–3, 1999.
- M. R. Awad, A. El-Gamel, P. Hasleton, D. M. Turner, P. J. Sinnott, and I. V. Hutchinson, “Genotypic variation in the transforming growth factor-β1 gene: association with transforming growth factor-β1 production, fibrotic lung disease, and graft fibrosis after lung transplantation,” Transplantation, vol. 66, no. 8, pp. 1014–1020, 1998.
- C. M. Probst, E. P. Bompeixe, N. F. Pereira et al., “HLA polymorphism and evaluation of European, African, and Amerindian contribution to the white and mulatto populations from Paraná, Brazil,” Human Biology, vol. 72, no. 4, pp. 597–617, 2000.
- D. Solomon and R. Nayar, Bethesda System for Cervical-Vaginal Cytology, Revinter, Rio de Janeiro, Brazil, 2005.
- D. C. Szurkus and T. A. Harrison, “Loop excision for high-grade squamous intraepithelial lesion on cytology: correlation with colposcopic and histologic findings,” American Journal of Obstetrics and Gynecology, vol. 188, no. 5, pp. 1180–1182, 2003.
- W. Qu, G. Jiang, Y. Cruz et al., “PCR detection of human papillomavirus: comparison between MY09/MY11 and GP5+/GP6+ primer systems,” Journal of Clinical Microbiology, vol. 35, no. 6, pp. 1304–1310, 1997.
- E. Santiago, L. Camacho, M. L. Junquera, and F. Vázquez, “Full HPV typing by a single restriction enzyme,” Journal of Clinical Virology, vol. 37, no. 1, pp. 38–46, 2006.
- M. P. Martin, G. Nelson, J.-H. Lee et al., “Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles,” Journal of Immunology, vol. 169, no. 6, pp. 2818–2822, 2002.
- C. C. C. Rudnick, G. A. S. Guelsin, A. V. Marangon, D. S. A. Franceschi, A. M. Sell, and J. E. L. Visentainer, “Methodology optimization for KIR genotyping,” Jornal Brasileiro de Patologia e Medicina Laboratorial, vol. 46, no. 3, pp. 215–224, 2010.
- M. Carrington and P. Norman, The KIR Gene Cluster, National Library of Medicine (US), NCBI, Bethesda, Md, USA, 2003.
- E. W. Petersdorf, “Risk assessment in haematopoietic stem cell transplantation: histocompatibility,” Best Practice and Research: Clinical Haematology, vol. 20, no. 2, pp. 155–170, 2007.
- S. W. Guo and E. A. Thompson, “Performing the exact test of Hardy-Weinberg proportion for multiple alleles,” Biometrics, vol. 48, no. 2, pp. 361–372, 1992.
- C. C. C. Rudnick, D. S. A. Franceschi, A. V. Marangon, G. A. S. Guelsin, A. M. Sell, and J. E. L. Visentainer, “Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná,” Human Immunology, vol. 69, no. 12, pp. 872–876, 2008.
- J. E. L. Visentainer, A. M. Sell, G. C. Da Silva et al., “TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil,” International Journal of Immunogenetics, vol. 35, no. 4-5, pp. 287–293, 2008.
- E. M. Burd, “Human papillomavirus and cervical cancer,” Clinical Microbiology Reviews, vol. 16, no. 1, pp. 1–17, 2003.
- M. P. Martin, I. B. Borecki, Z. Zhang et al., “HLA-Cw group 1 ligands for KIR increase susceptibility to invasive cervical cancer,” Immunogenetics, vol. 62, no. 11-12, pp. 761–765, 2010.
- M. Han, M. Fallena, Y. Guo, and P. Stastny, “Natural killer cell crossmatch: functional analysis of inhibitory killer immunoglobulin-like receptors and their HLA ligands,” Human Immunology, vol. 68, no. 6, pp. 507–513, 2007.
- M. J. Song, C. W. Lee, J. H. Kim, et al., “Association of KIR genes and HLA-C alleles with HPV-related uterine cervical disease in Korean women,” Tissue Antigens, vol. 81, no. 03, pp. 164–170, 2013.
- S.-I. Yusa, T. L. Catina, and K. S. Campbell, “KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2),” Journal of Immunology, vol. 172, no. 12, pp. 7385–7392, 2004.
- Z.-M. Lu, Y.-L. Jiao, Z.-L. Feng et al., “Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population,” Croatian Medical Journal, vol. 48, no. 6, pp. 800–806, 2007.
- M. Carrington, S. Wang, M. P. Martin et al., “Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci,” Journal of Experimental Medicine, vol. 201, no. 7, pp. 1069–1075, 2005.
- L. Arnheim, J. Dillner, and C. B. Sanjeevi, “A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia,” Tissue Antigens, vol. 65, no. 3, pp. 252–259, 2005.
- M. M. Madeleine, B. Brumback, K. L. Cushing-Haugen et al., “Human leukocyte antigen class II and cervical cancer risk: a population-based study,” Journal of Infectious Diseases, vol. 186, no. 11, pp. 1565–1574, 2002.
- P. Parham, “MHC class I molecules and KIRS in human history, health and survival,” Nature Reviews Immunology, vol. 5, no. 3, pp. 201–214, 2005.
- K. Chattopadhyay, “A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer,” Indian Journal of Human Genetics, vol. 17, no. 3, pp. 132–144, 2011.
- Y.-C. Yang, T.-Y. Chang, Y.-J. Lee et al., “HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis,” Human Immunology, vol. 67, no. 4-5, pp. 331–340, 2006.
- S. Ades, A. Koushik, E. Duarte-Franco et al., “Selected class I and class II HLA alleles and haplotypes and risk of high-grade cervical intraepithelial neoplasia,” International Journal of Cancer, vol. 122, no. 12, pp. 2820–2826, 2008.
- A. Guzalinuer, A. Mihrinsa, S.-Q. Zhang, H. Li, N. Gulishare, and G.-Q. Zhang, “Association between HPV infection and HLA-DQB1 alleles polymorphism in the cervical carcinogenesis in Uyghur women in southern Xinjiang,” Zhonghua Zhong Liu Za Zhi, vol. 32, no. 7, pp. 492–496, 2010.
- I. Kohaar, S. Hussain, N. Thakur et al., “Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women,” Human Immunology, vol. 70, no. 4, pp. 222–229, 2009.
- D. M. Hernández-Hernández, R. M. Cerda-Flores, T. Juárez-Cedillo et al., “Human leukocyte antigens I and II haplotypes associated with human papillomavirus 16-positive invasive cervical cancer in Mexican women,” International Journal of Gynecological Cancer, vol. 19, no. 6, pp. 1099–1106, 2009.
- Y. Ben Othmane, E. Ghazouani, A. Mezlini, et al., “HLA class II susceptibility to cervical cancer among Tunisian women,” Bull Cancer, vol. 99, no. 9, pp. 81–86, 2012.
- F. A. Castro, K. Haimila, I. Sareneva et al., “Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population—a candidate gene approach,” International Journal of Cancer, vol. 125, no. 8, pp. 1851–1858, 2009.
- P. C. Maciag, N. F. Schlecht, P. S. A. Souza, E. L. Franco, L. L. Villa, and M. L. Petzl-Erler, “Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women,” Cancer Epidemiology Biomarkers & Prevention, vol. 9, no. 11, pp. 1183–1191, 2000.
- J. Cervantes, C. Lema, L. V. Hurtado et al., “HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women,” Human Immunology, vol. 64, no. 9, pp. 890–895, 2003.
- K. Eiguchi, S. Tatti, L. V. Alonio et al., “Association of DRB1 and DQB1 HLA class II polymorphisms in high-grade and neoplastic cervical lesions of women from Argentina,” Journal of Lower Genital Tract Disease, vol. 12, no. 4, pp. 262–268, 2008.
- C. Alaez-Verson, J. Berumen-Campos, A. Munguía-Saldaña et al., “HPV-16 and HLA-DRB1 alleles are associated with cervical carcinoma in Mexican Mestizo women,” Archives of Medical Research, vol. 42, no. 5, pp. 421–425, 2011.
- L.-C. Chuang, C.-Y. Hu, H.-C. Chen et al., “Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk,” Cancer, vol. 118, no. 1, pp. 223–231, 2012.
- D. D. Dao, C. H. Sierra-Torres, S. C. Robazetti et al., “HLA-DQB1 and cervical cancer in Venezuelan women,” Gynecologic Oncology, vol. 96, no. 2, pp. 349–354, 2005.
- C. Lema, A. L. Fuessel-Haws, L. R. Lewis et al., “Association between HLA-DQB1 and cervical dysplasia in Vietnamese women,” International Journal of Gynecological Cancer, vol. 16, no. 3, pp. 1269–1277, 2006.
- J. Liang, A. Xu, Y. Xie, A. O. Awonuga, and Z. Lin, “Some but not all of HLA-II alleles are associated with cervical cancer in Chinese women,” Cancer Genetics and Cytogenetics, vol. 187, no. 2, pp. 95–100, 2008.
- Y. Wu, B. Liu, W. Lin et al., “Human leukocyte antigen class II alleles and risk of cervical cancer in China,” Human Immunology, vol. 68, no. 3, pp. 192–200, 2007.
- P. S. De Araujo Souza and L. L. Villa, “Genetic susceptibility to infection with human papillomavirus and development of cervical cancer in women in Brazil,” Mutation Research, vol. 544, no. 2-3, pp. 375–383, 2003.
- K. Matsumoto, H. Maeda, A. Oki et al., “HLA class II DRB1*1302 allele protects against progression to cervical intraepithelial neoplasia grade 3: a multicenter prospective cohort study,” International Journal of Gynecological Cancer, vol. 22, no. 3, pp. 471–478, 2012.
- P. K. S. Chan, J. L. K. Cheung, T.-H. Cheung et al., “HLA-DQB1 polymorphisms and risk for cervical cancer: a case-control study in a southern Chinese population,” Gynecologic Oncology, vol. 105, no. 3, pp. 736–741, 2007.
- D. Chen, I. Juko-Pecirep, J. Hammer, et al., “Genome-wide association study of susceptibility loci for cervical cancer,” Journal of the National Cancer Institute, vol. 105, no. 9, pp. 624–633, 2013.
- Q. Feng, H. Wei, J. Morihara, et al., “Th2 type inflammation promotes the gradual progression of HPV-infected cervical cells to cervical carcinoma,” Gynecologic Oncology, vol. 127, no. 2, pp. 412–419, 2012.
- L. F. Telesheva, V. F. Dolgushina, O. S. Abramovskikh, et al., “Cytokine status of cervical mucus in women with transitory and persistent course of papillomavirus infection,” Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii, vol. 4, pp. 118–121, 2012.
- A. Bolpetti, J. S. Silva, L. L. Villa, and A. P. Lepique, “Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth,” BMC Immunology, vol. 11, article 27, 2010.
- G. Barbisan, L. O. Pérez, A. Contreras, et al., “TNF- and IL-10 promoter polymorphisms, HPV infection, and cervical cancer risk,” Tumor Biology, vol. 33, no. 5, pp. 1549–1556, 2012.
- I. V. Iancu, A. Botezatu, C. D. Goia-Ruşanu et al., “TGF-beta signalling pathway factors in HPV-induced cervical lesions,” Roumanian Archives of Microbiology and Immunology, vol. 69, no. 3, pp. 113–118, 2010.
- S. Mocellin and D. Nitti, “TNF and cancer: the two sides of the coin,” Frontiers in Bioscience, vol. 13, no. 7, pp. 2774–2783, 2008.
- N. Wang, D. Yin, S. Zhang et al., “TNF-alpha rs1800629 polymorphism is not associated with HPV infection or cervical cancer in the Chinese population,” PLoS ONE, vol. 7, no. 9, Article ID e44952, 2012.
- I. Badano, S. M. Stietz, T. G. Schurr et al., “Analysis of TNFα promoter SNPs and the risk of cervical cancer in urban populations of Posadas (Misiones, Argentina),” Journal of Clinical Virology, vol. 53, no. 1, pp. 54–59, 2012.
- T. Y. Shi, M. L. Zhu, J. He, et al., “Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women,” Human Genetics, vol. 132, no. 3, pp. 301–312, 2013.