Research Article

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Table 4

Combinations of inhibitory KIR-HLA pairs and their frequencies in HPV and control Brazilian women from Paraná, Southern Brazil.

Number of pairs KIR-HLAHPV patients
(%)
Control
(%)

1 pair2DL2/3-C13 (30.0)7 (61.5)
2DL1-C27 (70.0)4 (38.5)

2 pairs2DL2/3-C1, 3DL1-Bw412 (46.2)16 (34.5)
2DL2/3-C1, 2DL1-C27 (26.9)14 (29.0)
2DL1-C2, 3DL1-Bw44 (15.4)11 (23.6)
2DL1-C2, 3DL2-A3/112 (7.7)4 (9.1)
2DL2/3-C1, 3DL2-A3/111 (3.9)2 (3.7)

3 pairs2DL1-C2, 2DL2/3-C1, 3DL1-Bw414 (51.9)25 (76.3)
2DL2/3-C1, 3DL1-Bw4, 3DL2-A3/11a7 (25.9)2 (5.3)
2DL1-C2, 2DL2/3-C1, 3DL2-A3/116 (23.0)5 (15.8)
2DL1-C2, 3DL1-Bw4, 3DL2-A3/110 (0) 1 (2.6)

4 pairs2DL1-C2, 2DL2/3-C1, 3DL1-Bw4, 3DL2-A3/118 (100)12 (100)

; OR = 3.42; 95% CI = 2.45–18.22.