Research Article
The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population
Table 8
Expected phenotype frequencies according to genotypes for the cytokines TNF-
, IFN-
, IL-6, IL-10, and TGF-
β1.
| Phenotypes | Genotypes | Patients () (%) | Controls () (%) |
| | TNF | | | Low | G/G | 62 (78.48) | 73 (72.28) | High | G/A |
17 (21.52) |
28 (27.72) | A/A |
| | IL6 | | | High | G/G |
72 (91.14) |
87 (86.14) | G/C | Low | C/C | 7 (8.86) | 14 (13.86) |
| | INFG | | | High | T/T | 19 (24.36) | 19 (19.39) | Intermediate | T/A | 31 (39.74) | 50 (51.02) | Lowb | A/A | 28 (35.90) | 29 (29.59) |
| | IL10 | | | High | GCC/GCC | 16 (20.51) | 12 (12.00) | Intermediatea | GCC/ACC |
25 (32.05) |
48 (48.00) | GCC/ATA | Low | ACC/ACC |
37 (47.44) |
40 (40.00) | ACC/ATA | ATA/ATA |
| | TGFB1 | | | High | T/T G/G |
52 (65.82) |
78 (78.00) | T/C G/G | Intermediate | T/C G/C |
22 (27.85) |
17 (17.00) | C/C G/G | T/T G/C | Low | C/C G/C |
5 (6.33) |
5 (5.00) | C/C C/C | T/T C/C | T/C C/C |
|
|
: number of excepted phenotypes according to genotypes. %: frequencies.
a; OR = 0.1607; 95% CI = 0.276–0.947.
b; OR = 1.81; 95% CI = 1.178–4.604.
|