Table 3: Pharmacokinetics parameters in rats after i.v. administration of F-DTX and oral administration of F-DTX and Ch20-GSH-DTX NPs at the same 10 mg/kg drug dose.

PK ParametersF-DTX (IV)F-DTX (oral)Ch20-GSH NPs (oral)

(h)0.525
(ng/mL)14,744 ± 2,354456 ± 54.1341 ± 47.5
(h ng/mL)65,245 ± 4,5454,243 ± 20744,998 ± 3,534
(h)2.7 ± 0.611.7 ± 1.45102.5 ± 12.6
MRT (h)3.2 ± 0.315.7 ± 1.6144.0 ± 10.7
Absolute bioavailability6.5%
Relative bioavailability68.9%