Perinatal Exposure to Insecticide Methamidophos Suppressed Production of Proinflammatory Cytokines Responding to Virus Infection in Lung Tissues in Mice

Table 2

Effects of methamidophos on cytokine levels in BALF and pulmonary viral titers in RSV-infected offspring mice.

Methamidophos (ppm)	Day 1 after infection					Day 5 after infection
	Cytokine level in BALF (ng/mL)					Cytokine level in BALF (ng/mL)			Pulmonary viral titer (copy/mL)
	TNF-α	IL-6	IL-1β	IL-12	G-CSF	IFN-γ	IL-4	IL-10
0	0.83 (0.24)	0.50 (0.10)	<0.04	<0.08	0.08 (0.01)	1.50 (0.47)	<0.04	0.26 (0.13)	3.4×10^5 (1.3×10^5)
10	0.68 (0.28)	0.33* (0.02)	<0.04	<0.08	0.07 (0.01)	1.33 (0.78)	<0.04	0.25 (0.13)	—
20	0.53 (0.18)	0.25** (0.07)	<0.04	<0.08	0.06 (0.01)	0.81* (0.38)	<0.04	0.14 (0.02)	2.5×10^5 (4.0×10^4)

Data represent mean of values of 6 mice. Numbers in parentheses indicate standard deviation of values.
*Significantly different from control at 𝑃<0.05 (Student’s 𝑡-test).
**Significantly different from control at 𝑃<0.01 (Student’s 𝑡-test).