152909.fig.002a
(a) Nth1 +/+ + t-BOOH
152909.fig.002b
(b) Nth1 +/+ + t-BOOH
152909.fig.002c
(c) Nth1 −/− + t-BOOH
152909.fig.002d
(d) Nth1 −/− + t-BOOH
Figure 2: MTT and clonogenic survival curves for t-BOOH treatment of Nth1 +/+ and Nth1 −/− MEFs with and without reduced Msh2 expression. MTT (a) and clonogenic survival (b) curves for Nth1 +/+ + pshRNAMsh2283, clone 2 (88% Msh2 gene silencing; black square) and Nth1 +/+ + pshRNA empty (grey square) treated with t-BOOH. MTT (c) and clonogenic survival (d) curves for Nth1 −/− + pshRNAMsh2283, clone 1 (85% Msh2 gene silencing; solid square), or Nth1 −/− + pshRNA empty (grey square) treated with t-BOOH. Results are expressed as mean ± SEM; , , and .