152909.fig.003a
(a) Mpg +/+ + t-BOOH
152909.fig.003b
(b) Mpg +/+ + t-BOOH
152909.fig.003c
(c) Mpg −/− + t-BOOH
152909.fig.003d
(d) Mpg −/− + t-BOOH
Figure 3: MTT and clonogenic survival curves for t-BOOH treatment of Mpg +/+ and Mpg −/− MEFs with and without reduced Msh2 expression. MTT (a) and clonogenic survival (b) curves for Mpg +/+ + pshRNAMsh2283, clone 9 (85% Msh2 gene silencing; black square), or Mpg +/+ + pshRNA empty (grey square) cells treated with t-BOOH. MTT (c) and clonogenic survival (d) curves for Mpg −/− + pshRNAMsh2283, clone 1 (79% Msh2 gene silencing; solid square), or Mpg −/− + pshRNA empty (grey square) cells treated with t-BOOH. Results are expressed as mean ± SEM; , , and .