152909.fig.004a
(a) Nth1 +/+ + KBrO3
152909.fig.004b
(b) Nth1 +/+ + KBrO3
152909.fig.004c
(c) Nth1 −/− + KBrO3
152909.fig.004d
(d) Nth1 −/− + KBrO3
Figure 4: MTT and clonogenic survival curves for KBrO3 treatment of Nth1 +/+ and Nth1 −/− MEFs with and without reduced Msh2 expression. MTT (a) and clonogenic survival (b) curves for Nth1 +/+ + pshRNAMsh2283, clone 2 (88% Msh2 gene silencing; black square), and Nth1 +/+ + pshRNA empty (grey square) treated with KBrO3. MTT (c) and clonogenic survival (d) curves for Nth1 −/− + pshRNAMsh2283, clone 1 (85% Msh2 gene silencing; solid square), or Nth1 −/− + pshRNA empty (grey square) treated with KBrO3.