1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modelling Studies
Figure 3
(a) Evaluation of phosphorylated and total VEGFR-2 expression in HUVECs after incubation with compounds 2a, 2b, and 2c by western blotting. Representative bands obtained after immunostaining are shown. (b) Quantification of densitometry and mean relative intensity by comparison of the relative intensity of activated VEGFR-2 after normalization with total VEGFR-2 intensity. Data presented as mean ± SEM of two independent experiments. * versus control.
