1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modelling Studies
Figure 4
(a) Superimposition of the docking poses at the VEGFR-2 kinase domain for compounds: 2a (cyan), 2b (green) and 2c (orange). (b) Surface representation of the VEGFR-2 kinase hinge with the docking poses of compounds 2c (orange)and 2f (light grey). H-bonds are depicted in dashed yellow lines (distances between 2.9 and 3.3 Å) and hydrophobic interactions are depicted in dashed white lines (distances between 3.5 and 4.0 Å). Important residues are drawn in sticks. Figures were prepared using PyMOL [19].
