1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modelling Studies

Table 1

Results of the VEGFR2 enzymatic inhibition assay using compounds 2a–f.

Compounds	VEGFR-2; IC50 (𝜇M)^a
2a	0.199
2b	0.188
2c	0.150
2d	>100
2e	>100
2f	>100

aEach IC₅₀ determination is a result of four separate determinations.