Effect of Ex Vivo Culture Conditions on Immunosuppression by Human Mesenchymal Stem Cells

Table 1

List of selected genes highly expressed in MSCs harvested at high cell confluence (>90%).

Abbr.*	Full name	FC	Adjusted; 𝑃-value	Biological function	Gene ontology category
PTGES	Prostaglandin E synthase	2.40	<1.00𝐸−04	Involved in TP53-induced apoptosis and acute inflammatory responses [16]	GO:0006693_prostaglandin metabolic process; GO:0007165_signal transduction
ULBP1	UL16 binding protein	2.01	<1.00𝐸−04	Associated with NKG2D-mediated immunity [18]	GO:0019882_antigen processing and; presentation; GO:0050776_regulation of immune; response

∗Abbr.: abbreviation.
Fold change (FC) is for comparison between MSCs harvested at high cell confluence (~90%) and at low cell confluence (~50%). Positive values indicate higher expression in MSCs harvested at high cell density.