Effect of Complexation with Arabinogalactan on Pharmacokinetics of “Guest” Drugs in Rats: For Example, Warfarin

Table 1

Pharmacokinetic parameters of WF and 1 : 10 WF : AG.

	1 : 10 WF : AG	Warfarin
𝜆z, 10^−2 h^−1	6.70±2.30^∗	3.00±0.20
𝐶max_ss, 𝜇g/mL	3.85±1.40^∗	9.12±1.40
𝐶min_ss, 𝜇g/mL	0.17±0.30^∗	1.31±0.13
𝑇max_ss, h	51.40±1.30	50.50±1.70
𝐶av, μg/mL	1.29±0.38^∗	5.42±1.89
Cl/F, mL/h	2.98±1.25^∗	0.84±0.10
𝑉𝑑/F, mL/kg	36.93±3.70^∗	26.23±5.67
𝑇1/2(z), h	11.64±4.85^∗	23.41±1.40
AUC(tau)ss, 𝜇g h/mL	30.95±9.19^∗	130.25±45.25
AUMC(tau)ss, μg h^2/mL	310.25±149.79^∗	2501.23±313.23
MRT, h	12.45±3.08^∗	16.55±0.58

^∗𝑝<0.05 from warfarin.