Release of IL-1β Triggered by Milan Summer PM₁₀: Molecular Pathways Involved in the Cytokine Release

Figure 3

PM₁₀-induced IL-1β release dependent on caspase-1 activation in THP-1-derived macrophages cells. The cells were pretreated with the caspase-1 inhibitor, z-YVAD-fmk (10 μM) for 1 h, and exposed to summer PM₁₀ for 6 h. Results are the mean and s.d. of three independent experiments. CTRL: untreated cells. ^∗∗∗𝑃<0.001 versus CTRL, ^###𝑃<0.001 versus summer PM₁₀.