Research Article
Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity
Table 3
Clastogenicity study upon short term exposure (4 h) of NR-INF-02 in the absence of metabolic activation in human blood lymphocytes.
| Treatment
| Vehicle control |
Positive control MMC (0.20 µg/mL) |
NR-INF-02 (2500.00 µg/mL) |
NR-INF-02 (791.14 µg/mL) |
NR-INF-02 (250.36 µg/mL) | R1 | R2 | R1 | R2 | R1 | R2 | R1 | R2 | R1 | R2 |
| Total number of metaphase analyzed | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | Normal | 99 | 100 | 92 | 92 | 98 | 97 | 98 | 96 | 98 | 100 | Chromatid break | 1 | — | — | 4 | 1 | — | 1 | — | — | — | Chromosome break | — | — | — | 1 | — | 1 | — | — | — | — | Deletion | — | — | — | 1 | — | — | — | — | 1 | — | Ring | — | — | 3 | 1 | 1 | — | — | — | 1 | — | Dicentric | — | — | 5 | 1 | — | 2 | — | 1 | — | — | Fragment | — | — | — | — | — | — | — | 1 | — | — | Gap | — | — | — | — | — | — | 1 | 1 | — | — | Ploidy | — | — | — | — | — | — | — | 1 | — | — | Endoreduplication | — | — | — | — | — | — | — | — | — | — | Total aberrations | 1 | 0 | 8 | 8 | 2 | 3 | 1 | 1 | 2 | 0 | Total aberrations (Mean ± SD) | | | | | | Mitotic Index (Mean ± SD) | | | | | |
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R: replicate; ; MMC: mitomycin C; Ploidy, endoreduplication, gaps, and fragments are not considered as aberrations for calculations.
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