Safety Evaluation of Turmeric Polysaccharide Extract: Assessment of Mutagenicity and Acute Oral Toxicity

Table 6

Effect of NR-INF-02 on micronucleus induction in CHO-K1 cells.

Treatment (µg/mL)	MN-BN cells (%)	CBPI
	Mean ± SD	Mean ± SD
Without S9 short term exposure (4 h)
Vehicle control	0.15±0.07	1.80±0.01
NR-INF-02 (250.36 µg/mL)	0.00±0.00	1.78±0.03
NR-INF-02 (791.14 µg/mL)	0.00±0.00	1.78±0.01
NR-INF-02 (2500.00 µg/mL)	0.00±0.00	1.77±0.01
Positive control; MMC (0.2 µg/mL)	0.50±0.14^∗	1.66±0.03^∗
With S9 short term exposure (4 h)
Vehicle control	0.00±0.00	1.80±0.01
NR-INF-02 (250.36 µg/mL)	0.05±0.07	1.80±0.04
NR-INF-02 (791.14 µg/mL)	0.00±0.00	1.80±0.01
NR-INF-02 (2500.0 µg/mL)	0.00±0.00	1.80±0.04
Positive control; B[a]P (20.0 µg/mL)	1.6±0.28^∗	1.70±0.03
Without S9 long term exposure (18 h)
Vehicle control	0.00±0.00	1.86±0.00
NR-INF-02 (250.36 µg/mL)	0.10±0.00	1.87±0.02
NR-INF-02 (791.14 µg/mL)	0.00±0.00	1.86±0.01
NR-INF-02 (2500.0 µg/mL)	0.15±0.07	1.84±0.01
Positive control; MMC (0.2 µg/mL)	4.55±0.78^∗	1.58±0.04^∗

^∗𝑃<0.05; MMC: mitomycin C; B[a]P: benzo[a]pyrene.