Gemifloxacin, a Fluoroquinolone Antimicrobial Drug, Inhibits Migration and Invasion of Human Colon Cancer Cells
Figure 1
GMF decreased cell migration and invasion in SW620 and LoVo colon cancer cells. (a) The effect of GMF on viability of the SW620 and LoVo cells. GMF reduced cell migration as determined by wound healing analysis (b) and the transwell system (c). (d) GMF decreased cell invasion. The migration and invasion abilities of the SW620 and LoVo cells were quantified by QCM 24-well Cell Migration and Invasion assay kits, as described in Section 2. Ten percent of FBS acted as the chemoattractant for cancer migration and invasion. All results are representative of at least three independent experiments. Each value is the mean ± SD of three determinations. The asterisk (*) indicates a significant difference between the two test groups, as analyzed by Student’s t test ().
