LPS Increases MUC5AC by TACE/TGF-α/EGFR Pathway in Human Intrahepatic Biliary Epithelial Cell
Figure 5
Inhibiting TACE blocked LPS-induced MUC5AC expression in HIBECs. (a) ELISA analysis showing that LPS increased TGF-α secretion in HIBECs, and this is inhibited by TAPI-1 treatment, a TACE inhibitor. ((b)–(d)) Western blot analysis showing that TAPI-1 inhibited LPS-induced pEGFR and MUC5AC protein expression. Protein levels were measure by MUC5AC/β-actin. *.
