Lifting the Silver Flakes: The Pathogenesis and Management of Chronic Plaque Psoriasis

Table 2

A summary of combination treatments for-mild-to severe psoriasis vulgaris. Results are tabulated from findings from a recent systematic review and meta-analysis [27].

Combination treatment for psoriasis
Agents	Outcomes
Topical vitamin D analogues and corticosteroids	Patients had a 22% (95% CI: 12%–33%) increased likelihood of clearance than did patients receiving vitamin D derivative monotherapy
Topical vitamin D analogues and UV-B phototherapy	Patients had no statistically significant increase (11%; 95% CI: 2%–24%) in the likelihood of clearance than did patients receiving UV-B monotherapy
Topical retinoids and vitamin D analogues	Patients had a 33% (95% CI: 22%–44%) increased likelihood clearance than did patients receiving topical retinoids monotherapy
Topical corticosteroids and salicylic acid	Patients had no statistically significant increase (3%; 95% CI: 0%–7%) in the likelihood of clearance than did patients receiving UV-B monotherapy
Topical corticosteroids and UV-B phototherapy	Patients had no statistically significant increase (−6%; 95% CI: −24%–12%) in the likelihood of clearance than did patients receiving UV-B monotherapy
Topical retinoids and corticosteroids	Patients had a 19% (95% CI: 11%–27%) increased likelihood of clearance than did patients receiving vitamin A derivative monotherapy
Topical retinoids and UV-B phototherapy	Patients had a 21% (95% CI: 5%–36%) increased likelihood of clearance than did patients receiving UV-B monotherapy
UV-B phototherapy and biological agents	Patients had a 68% (95% CI: 51%–85%) increased likelihood of clearance than did patients receiving alefacept monotherapy
UV-B phototherapy and methotrexate	Patients had a 36% (95% CI: 10%–63%) increased likelihood clearance than did patients receiving UV-B-methotrexate monotherapy