In Silico Prediction and In Vitro Characterization of Multifunctional Human RNase3

Table 3

Correlation of HBR motifs and characteristic functions of hRNase3.

Location	Function
	RNase	Cytotoxicity	Cell binding activity	HS binding activity	Endocytic activity	Lipid binding activity
RNase3	O	O	O	O	O	O
HBR1-mt RNase3	No activity	Decrease 50%	Increase 50%	Decrease 40%	No activity
HBR2-mt RNase3	Similar	Similar	Decrease 20%	Similar	Decrease 50%
HBR3-mt RNase3	Decrease 30%	No activity	Decrease 20%	Similar	Similar
HBPRNase3(32−41)	X	X	O	O	ND	O

Note: O, X, and ND, respectively, represent active, inactive, and not determined.