Computational Analysis of the Soluble Form of the Intracellular Chloride Ion Channel Protein CLIC1
Figure 3
Conformational changes around the GSH-binding site in the apo1 simulation. (a) Global structural changes. Stereo pair in cartoon representation of the superimposed trajectory frames corresponding to the maximum (yellow, ns) and minimum (green, ns) projection structures for EV1 from the apo1 simulation. The view is similar to that in Figure 1. Tyr233 and Cys24 from the maximum projection structure are depicted in ball and stick and coloured red. Secondary structural elements discussed in the text are as indicated. (b)-(c) Interaction of Tyr233 and Cys24. Residues shown in stick form with carbon coloured cyan, oxygen red, nitrogen blue, and sulphur orange. Hydrogen bonds are shown as red dashed lines. (b) ns, (c) ns.
