Computational Analysis of the Soluble Form of the Intracellular Chloride Ion Channel Protein CLIC1

Figure 4

Correspondence between MD and GNM analysis of protein dynamics. Per residue plot of RMS fluctuations of C𝛼 atoms derived from PCA of apo simulation 1 (EV1) are in black. Foot loop residues 145–165 were not included in the PCA analysis. The fluctuation profile predicted by GNM analysis for slow mode 5 is in grey. The GNM data are scaled to fit the range of the MD data for the purposes of comparison.