Downregulation of DLC-1 Gene by Promoter Methylation during Primary Colorectal Cancer Progression

Table 2

Patients’ basic clinical characteristics and molecular alternation information.

	Normal mucosa	Adenomas	Carcinomas	𝑃 value
Age (y)
<60	19	19	33	0.631
≥60	29	38	47
Gender
Female	18	28	45	0.121
Male	30	29	35
DLC-1 methylation
Nonmethylation	43	31	32	<0.001
Partial methylation	5	18	19
Extensive methylation	0	8	29
DLC-1 mRNA expression
Abundant	41	27	17	<0.001
Reduction	7	30	63
KRAS
Wild-type	44	47	48	<0.001
Mutation	4	10	32
BRAF
Wild-type	47	55	78	0.894
Mutation	1	2	2