Research Article
Downregulation of DLC-1 Gene by Promoter Methylation during Primary Colorectal Cancer Progression
Table 3
Methylation status, pathological features, and molecular alternations in CRCs and adenomas.
| | CRCs | Adenomas | | | Non methylation | Partial methylation | Extensive methylation | value | Non methylation | Partial methylation | Extensive methylation | value |
| Age (y) | | | | | | | | | <60 | 14 | 4 | 15 | 0.098 | 8 | 8 | 3 | 0.397 | ≥60 | 18 | 15 | 14 | 23 | 10 | 5 | Gender | | | | | | | | | Female | 14 | 11 | 20 | 0.139 | 13 | 11 | 4 | 0.433 | Male | 18 | 8 | 9 | 18 | 7 | 4 | Location | | | | | | | | | Distal | 17 | 15 | 16 | 0.151 | 23 | 15 | 6 | 0.829 | Proximal | 15 | 4 | 13 | 8 | 3 | 2 | Dukes’ stage | | | | | | | | | A + B | 23 | 7 | 7 | 0.004 | | | | | C | 4 | 5 | 8 | | | | | D | 5 | 7 | 14 | | | | | Differentiation | | | | | | | | | Well and moderately | 19 | 9 | 11 | 0.259 | | | | | Poorly | 13 | 10 | 18 | | | | | Size | | | | | | | | | <1 cm | 14 | 7 | 13 | 0.88 | 14 | 6 | 2 | 0.598 | ≥1 cm | 18 | 12 | 16 | 17 | 12 | 6 | KRAS mutation status | | | | | | | | | Wild-type | 24 | 13 | 11 | 0.01 | 26 | 14 | 7 | 0.889 | Mutation | 8 | 6 | 18 | 5 | 4 | 1 |
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