Downregulation of DLC-1 Gene by Promoter Methylation during Primary Colorectal Cancer Progression

Table 3

Methylation status, pathological features, and molecular alternations in CRCs and adenomas.

	CRCs				Adenomas
	Non methylation	Partial methylation	Extensive methylation	𝑃 value	Non methylation	Partial methylation	Extensive methylation	𝑃 value
Age (y)
<60	14	4	15	0.098	8	8	3	0.397
≥60	18	15	14		23	10	5
Gender
Female	14	11	20	0.139	13	11	4	0.433
Male	18	8	9		18	7	4
Location
Distal	17	15	16	0.151	23	15	6	0.829
Proximal	15	4	13		8	3	2
Dukes’ stage
A + B	23	7	7	0.004
C	4	5	8
D	5	7	14
Differentiation
Well and moderately	19	9	11	0.259
Poorly	13	10	18
Size
<1 cm	14	7	13	0.88	14	6	2	0.598
≥1 cm	18	12	16		17	12	6
KRAS mutation status
Wild-type	24	13	11	0.01	26	14	7	0.889
Mutation	8	6	18		5	4	1