Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats

Table 1

Relative organ weights of rats receiving single dose of Euphorbia hirta extract for 14 days.

Organs	Treatment
	Control	Euphorbia  hirta extracts; 5000 mg/kg
Male
Heart	0.45±0.02	0.42±0.02
Liver	3.52±0.13	3.15±0.10^∗
Spleen	0.30±0.02	0.36±0.01^∗
Kidneys	0.83±0.02	0.85±0.02
Lungs	0.67±0.03	0.63±0.06
Female
Heart	0.46±0.02	0.44±0.02
Liver	3.69±0.16	3.56±0.15
Spleen	0.42±0.04	0.38±0.02
Kidneys	0.90±0.07	0.81±0.04
Lungs	0.82±0.03	0.83±0.05

Values are expressed as mean ± SEM (𝑛=6 for each group).
Relative organ weight was calculated as (organ weight/body weight) × 100%
^∗𝑃 values < 0.05 were considered significant using one-way ANOVA followed by Tukey’s multiple comparison tests. Asterisks denote significant difference compared to control.