Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats

Table 2

Effect of Euphorbia hirta extract on haematological parameters in acute oral toxicity study.

	Unit	Treatment
		Control	Euphorbia hirta extracts; 5000 mg/kg
Male
Haemoglobin	g/L	154.33±1.96	150.17±2.57
Total red blood cells	10^12/L	7.83±0.15	8.14±0.27
Packed cells volume	L/L	0.46±0.00	0.46±0.00
Mean corpuscular volume	fL	59.00±0.77	56.17±1.19
Mean corpuscular Hb	pg	19.67±0.21	18.67±0.56
Mean corpuscular Hb conc	g/L	334.50±5.89	330.17±8.67
Red blood cells distribution width	%	14.37±0.79	14.57±1.044
Total white blood cells	10^9/L	7.27±0.97	9.02±1.70
Neutrophils	%	20.83±3.03	27.33±3.27
Lymphocytes	%	73.33±2.28	69.33±3.17
Monocytes	%	3.00±0.73	2.00±0.37
Platelet count	10^9/L	866.00±120.33	1140.33±50.64
Female
Haemoglobin	g/L	141.17±5.52	142.83±4.90
Total red blood cells	10^12/L	7.48±0.26	7.28±0.18
Packed cells volume	L/L	0.41±0.03	0.44±0.011
Mean corpuscular volume	fL	55.33±0.01	60.50±1.18^∗
Mean corpuscular Hb	pg	19.00±0.26	19.67±0.42
Mean corpuscular Hb conc	g/L	341.83±6.67	324.17±6.89
Red blood cells distribution width	%	12.30±0.22	13.33±1.11
Total white blood cells	10^9/L	8.93±0.43	9.03±0.97
Neutrophils	%	19.17±3.05	16.00±1.84
Lymphocytes	%	74.33±3.34	79.83±1.30
Monocytes	%	4.50±0.99	3.67±1.085
Platelet count	10^9/L	844.67±147.75	995.67±55.01

Values are expressed as mean ± SEM (𝑛=6 for each group).
^∗𝑃 values < 0.05 were considered significant using one way ANOVA followed by Tukey’s multiple comparison tests. Asterisks denote significant difference compared to control.