Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats

Table 3

Effect of Euphorbia hirta extract on biochemical parameters in acute oral toxicity study.

	Unit	Treatment
		Control	Euphorbia hirta extracts 5000 mg/kg
Male
Sodium	mmol/L	140.83±0.70	140.83±0.60
Potassium	mmol/L	4.37±0.29	4.75±0.35
Chloride	mmol/L	102.83±0.83	104.50±1.06
Urea	mmol/L	5.65±0.52	6.083±0.36
Creatinine	𝜇mol/L	24.17±2.30	25.67±3.21
Uric acid	mmol/L	0.15±0.03	0.17±0.03
Total protein	g/L	61.50±1.82	62.67±0.95
Albumin	g/L	29.67±0.84	31.67±0.67
Globulin	g/L	31.83±1.17	31.00±1.18
Albumin/globulin ratio		0.93±0.03	1.02±0.05
Alkaline phosphatase	U/L	201.83±41.45	231.00±11.90
AST	U/L	196.00±7.31	184.33±19.22
ALT	U/L	44.67±1.45	49.167±3.65
Female
Sodium	mmol/L	140.00±0.82	139.83±0.91
Potassium	mmol/L	4.27±0.19	4.33±0.28
Chloride	mmol/L	105.17±1.35	102.67±1.23
Urea	mmol/L	8.12±0.59	7.38±0.61
Creatinine	𝜇mol/L	36.33±6.03	33.33±1.31
Uric acid	mmol/L	0.11±0.00	0.15±0.03
Total protein	g/L	62.33±1.43	64.50±1.80
Albumin	g/L	31.50±0.67	32.33±1.65
Globulin	g/L	30.83±1.51	32.17±1.30
Albumin/globulin ratio		1.02±0.05	1.00±0.07
Alkaline phosphatase	U/L	142.17±24.23	194.83±15.74
AST	U/L	139.83±17.18	202.17±22.27
ALT	U/L	32.67±2.96	46.33±1.86

Values are expressed as mean ± SEM (𝑛=6 for each group).
^∗𝑃 values < 0.05 were considered as significant using one way ANOVA followed by Tukey’s multiple comparison tests. Asterisks denote significant difference compared to control.