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BioMed Research International
Volume 2013 (2013), Article ID 182965, 11 pages
http://dx.doi.org/10.1155/2013/182965
Research Article

Expression and Function of NUMB in Odontogenesis

1Department of Orthodontics, College of Dental Medicine, Nova Southeastern University, 3200 S. University Drive, Fort Lauderdale, FL 33328, USA
2Brodie Tooth Development Genetics & Regenerative Medicine Research Laboratory, Department of Oral Biology (M/C 690), College of Dentistry, University of Illinois at Chicago, Chicago IL 60612, USA
3Department of Orthdontics, College of Dentistry, University of Illinois at Chicago, 801 S. Paulina Street, Chicago IL 60612, USA

Received 6 January 2013; Revised 2 May 2013; Accepted 13 May 2013

Academic Editor: Avina Paranjpe

Copyright © 2013 Haitao Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary figure 1: E16.5 mouse tooth germ was sectioned and immunostained with NUMB antibody. No NUMB expression was detected in these tooth germs. The right panel shows a higher resolution of the tooth germ.

Supplementary figure 2: Postnatal day 5 incisors were sectioned and immunostained for NUMB and activated Notch 1 antibodies, Activated Notch 1 expression was detected in ameloblasts, odontoblasts and dental pulp cells. Our results indicates both activated Notch 1 protein and NUMB protein are expressed in ameloblasts.

  1. Supplementary Figures